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Some stars have been doing their thing since they were little kids, but many more had relatively normal upbringings. These celebrities did — and they held perfectly normal jobs before becoming rich and famous.
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Nestled near the village of Rikhi, in the picturesque Namal Valley of the Mianwali District in Punjab, Pakistan, lies Namal Lake, a tranquil body of water that has played a vital role in the region’s history and development. This article delves into the rich history of Namal Lake, its significance, and the pressing challenges it faces today.<br/><br/>Historical Significance: Namal Lake owes its existence to the construction of Namal Dam in 1913 by British engineers. Its creation aimed to address the pressing issues of irrigation and drinking water scarcity in the region. The dam effectively formed a sizable lake, which, with normal rainfall, stands at an elevation of R.L. 1,160, about 20 feet below the crest of the weir. During average seasons, it can hold an impressive 630 million cubic feet of water, with a maximum capacity of 2,100 million cubic feet.<br/><br/>https://www.pakistantraveler.com/namal-lake/
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MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>
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Normal Video converte for 3D and cartoon
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Get ready for a dose of hilarious chaos in this incredible video!This clip captures the moment a dad attempts to serenade his daughter with a surprise concert.Prepare for laughter as the little one's peaceful world is turned upside down by her dad's enthusiastic (but perhaps not-so-melodic) vocals.Her wide-eyed stare and bewildered expression are pure comedy gold!<br/><br/>Video ID: <br/><br/>#funnybabyvideo #hilariousdadfails #babyhatessinging #viralvideo #dadsembarrassingserenade #babydevelopment #parentchildmoments #funnydadmoments #singingfails #cantstopwontstop #toocute #ohno #dadlife #momlife #lifewithkids #preciousmoments #caughtoncamera #failoftheday #bestofinternet #dailydoseofinternet #funnyfails #dadfail #daughterfather #bestof2024
⏲ 0:16 👁 235K
A woman had no idea she was pregnant until she went into labour while working a shift at Nando's - but is now thriving with her miracle son.<br/><br/>Destiny Stephens-Coull, 21, was doing her final year of college and had just been offered a place at university for the following year.<br/><br/>Like a normal 18-year-old, she went out clubbing on the weekends, wore crop tops and drank booze with friends.<br/><br/>She worked part-time at Nando's while living with her mum, Diane Coull, 55, a nursery assistant.<br/><br/>But everything changed when she showed up for a shift on April 13, 2022, and felt cramps like her period starting - even though she wasn't due on for two more weeks.<br/><br/>She ended up bleeding heavily in the toilet for over an hour - before being rushed to Basildon Hospital, Essex. <br/><br/>To her bewilderment, Destiny was told she was six months pregnant - despite having periods and gaining no weight, and needed an emergency c-section under general anaesthetic.<br/><br/>She awoke to meet her unexpected son, Kingsley, now two - who then had to fight for his life after being born 10 weeks premature on April 13, weighing 3lbs 1oz.<br/><br/>But two years on, both Destiny and her little boy are doing well. <br/><br/>The mum-of-one, from Laindon, Essex, said: \
⏲ 1:7 👁 85K
Indulge in a soulful journey of tranquility with our beautiful relaxing music, crafted to alleviate stress, promote restful sleep, and enhance meditation sessions. Let the soothing melodies serenade your soul, guiding you towards inner peace and relaxation.<br/><br/>#SerenadeYourSoul<br/>#RelaxingMusic<br/>#StressRelief<br/>#SleepAid<br/>#MeditationMusic<br/>#CalmingSounds<br/>#TranquilMelodies<br/>#InnerPeace<br/>#SoothingMusic<br/>#Mindfulness
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The Original Memphis Five was formed in 1917 by Phil Napoleon and Frank Signorelli.<br/><br/>They were not from Memphis.These were New York musicians.The band was named after W.C. Handy‘s song “Memphis Blues“.<br/><br/>Frank Signorelli had been in the Original Dixieland Jazz Band. <br/><br/>The Original Memphis Five used various names, including Ladd’s Black Aces, Jazzbo’s Carolina Serenaders, Bailey’s Lucky Seven, The Southland Six, and The Cotton Pickers.<br/><br/>Red Nichols, Miff Mole, and the Dorseys (Tommy and Jimmy Dorsey) also played in the band from time to time.<br/><br/>Phil Napoleon<br/>Charlie Panelli<br/>Jimmy Lytrell<br/>Frank SIgnorelli<br/>Jack Roth
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Perry Como sings “Lili Marlene” on RCA Victor 20-2824<br/><br/>Would you like to hear the story<br/>Of a girl that many soldiers know?<br/>It's a tale of love in all its glory<br/>They tell when the lights are soft an' low.<br/><br/>Underneath the lamp post by the barrack gates,<br/>Standing all alone every night you'll see her wait.<br/>She waits for a boy who marched away,<br/>And though he's gone, she hears him say<br/><br/>\
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Complete blood count or CBC test normal range – this video lecture is going to explain about the normal range of cbc test. This video will clear your doubts about the Complete blood count or CBC test normal range. So, if your doctor prescribed you to do a cbc test, watch this video to get to know about the normal range of cbc test. Knowing cbc test normal value is very important in order to prevent yourself from catching diseases in near future.<br/><br/><br/>Watch all videos on anemia here: <br/><br/><br/>We are social. Find us on different sites here-<br/>Our Website – www.https://kamleshkumartechnologist.blog...<br/>Facebook page- Kamlesh kumar-MLT<br/>https://web.facebook.com/profile.php?... <br/><br/><br/>Youtube- Kamlesh kumar-MLT<br/> UCKRg085ismwEPfA4yGECnSQ<br/><br/><br/>Thank you for watching the video lecture on Complete blood count or CBC test normal range.
⏲ 7:55 👁 10K
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